6-Tioguanine (6-TG) API Manufacturers
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Looking for 6-Tioguanine (6-TG) API 154-42-7?
- Description:
- Here you will find a list of producers, manufacturers and traders of Tioguanine. You can sort by certificates such as GMP, FDA, CEP, Written Confirmation and more. Send inquiries for free and get in direct contact with the supplier of your choice.
- API | Excipient name:
- 6-Tioguanine (6-TG)
- Synonyms:
- 6-TG , 6-Thioguanine , TG , ThG , Thioguanine , Tioguanin , Tioguanina , Tioguanine , Tioguaninum
- Cas Number:
- 154-42-7
- DrugBank number:
- DB00352
- Unique Ingredient Identifier:
- WIX31ZPX66
About Tioguanine
So, what does it do? An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.
You can ask the supplier about all relevant certificates for the product such as CoA, Safety Data Sheet and DMF.
6-Tioguanine (6-TG) is a type of Antimetabolites
Antimetabolites are a prominent category of pharmaceutical active pharmaceutical ingredients (APIs) utilized in the treatment of various diseases, particularly cancer. These compounds are structurally similar to naturally occurring metabolites essential for cellular processes such as DNA and RNA synthesis. By mimicking these metabolites, antimetabolites interfere with the normal functioning of cellular pathways, leading to inhibition of cancer cell growth and proliferation.
One of the widely used antimetabolites is methotrexate, a folic acid antagonist that inhibits the enzyme dihydrofolate reductase, disrupting the production of DNA and RNA. This disruption impedes the growth of rapidly dividing cancer cells. Another common antimetabolite is 5-fluorouracil (5-FU), which inhibits the enzyme thymidylate synthase, thereby interfering with DNA synthesis and inhibiting cancer cell proliferation.
Antimetabolites can be classified into several subcategories based on their mechanism of action and chemical structure. These include purine and pyrimidine analogs, folic acid antagonists, and pyrimidine synthesis inhibitors. Examples of antimetabolites in these subcategories include azathioprine, cytarabine, and gemcitabine.
Despite their effectiveness, antimetabolites can exhibit certain side effects due to their interference with normal cellular processes. These side effects may include gastrointestinal disturbances, myelosuppression (reduced production of blood cells), and hepatotoxicity.
In conclusion, antimetabolites are a vital category of pharmaceutical APIs used in the treatment of various diseases, especially cancer. By mimicking natural metabolites and disrupting crucial cellular processes, these compounds effectively inhibit cancer cell growth and proliferation. However, their usage should be carefully monitored due to potential side effects.
