Dimethyl fumarate API Manufacturers

compare suppliers & get competitive offers

Filters

Reset

Selected filters:

Type
Production region
Qualifications
Country of origin

TOP RANKING

Located in:

India

Produced in:

India

Established in: 1989

MOQ: -

Employees: 5000+

6 production facilities approved by USFDA, AGES-Austria, PMDA, WHO

R&D Centers with capabilities of ANDAs, DMFs and NDDS

462+ patents filed for drug substances and polymorphs

  • CoA

  • GMP

  • CEP

  • FDA

  • DMF

  • + 0

All certificates

  • DMF

  • WC

  • GMP

  • CoA

  • ISO9001

  • MSDS

  • BSE/TSE

Contact supplier

Replies quickly

TOP RANKING

Located in:

Iran

Distributor

Produced in:

Iran

Established in: 1956

MOQ: 1 kg

Employees: 200+

Expertise in Low Volume, High Value (LVHV) APIs

Technical knowledge for high-tech API production

therapeutic production sites with GMP compliance

  • CoA

  • GMP

  • CEP

  • FDA

  • DMF

  • + 0

All certificates

  • CoA

  • GMP

  • DMF

Contact supplier

Replies quickly

TOP RANKING

Located in:

India

Producer

Produced in:

India

Established in: 1984

MOQ: -

Employees: 21,650

Diverse portfolio of 180+APIs

1754+ DMF across global markets

1100+ patents filed, and more than 70 own patents granted

  • CoA

  • GMP

  • CEP

  • FDA

  • DMF

  • + 0

All certificates

  • DMF

  • WC

  • GMP

  • CoA

  • EDMF/ASMF

  • FDA

  • MSDS

  • BSE/TSE

Contact supplier

Replies quickly

HIGHLIGHTED

Located in:

Turkey

Producer

Produced in:

Turkey

Established in: 2022

MOQ: -

Employees: 100+

Operating on GMP guidelines with the most recent technologies and equipment

High-quality products at unrivaled prices

Specialize in Narcotic and Non-Narcotic APIs

  • CoA

  • GMP

  • CEP

  • FDA

  • DMF

  • + 0

All certificates

  • DMF

  • WC

  • GMP

  • CoA

  • MSDS

Contact supplier

Replies quickly

HIGHLIGHTED

Located in:

Netherlands

Produced in:

Netherlands

Established in: 1975

MOQ: 50 kg

Employees: 80+

State-of-the-art CMO & CRO facility

APIs for human & veterinary medicines

Development, analysing and production of APIs

  • CoA

  • GMP

  • CEP

  • FDA

  • DMF

  • + 0

All certificates

Contact supplier

Replies quickly

Produced in:

China

Established in: 2013

MOQ: 1 kg

Employees: 25+

ISO9001 certified

Drug R&D center (in Hangzhou)

From lab scale (mg/g) to commercial scale (kgs/tons)

  • CoA

  • GMP

  • CEP

  • FDA

  • DMF

  • + 0

All certificates

  • CoA

  • ISO9001

Contact supplier

Replies quickly

Distributor

Produced in:

World

Established in: 2005

MOQ: -

Employees: 200+

Portfolio of over 2,000 APIs

Precise quality control

End-to-end global regulatory support

  • CoA

  • GMP

  • CEP

  • FDA

  • DMF

  • + 0

All certificates

  • DMF

  • CEP

  • GMP

  • CoA

  • MSDS

  • BSE/TSE

Contact supplier

Replies quickly

Located in:

India
  • CoA

  • GMP

  • CEP

  • FDA

  • DMF

  • + 0

All certificates

  • DMF

  • CoA

Contact supplier

Replies slower than most

Located in:

China
  • CoA

  • GMP

  • CEP

  • FDA

  • DMF

  • + 0

All certificates

  • DMF

  • CoA

Contact supplier

Replies slower than most

Located in:

Czech Republic

Producer

  • CoA

  • GMP

  • CEP

  • FDA

  • DMF

  • + 0

All certificates

  • GMP

  • CoA

Contact supplier

Replies slower than most

Located in:

Germany

Producer

  • CoA

  • GMP

  • CEP

  • FDA

  • DMF

  • + 0

All certificates

  • CoA

  • DMF

Contact supplier

Replies slower than most

Located in:

India
  • CoA

  • GMP

  • CEP

  • FDA

  • DMF

  • + 0

All certificates

  • DMF

  • CoA

Contact supplier

Replies slower than most

Producer

Produced in:

Unknown

Established in: 1944

MOQ: -

Employees: 4,000

14 international API plant sites

Portfolio of 350+ APIs

Teva is among the world’s largest generic drug/API manufacturers

  • CoA

  • GMP

  • CEP

  • FDA

  • DMF

  • + 0

All certificates

  • DMF

  • CoA

Contact supplier

Replies quickly

Located in:

China
  • CoA

  • GMP

  • CEP

  • FDA

  • DMF

  • + 0

All certificates

  • DMF

  • CoA

Contact supplier

Replies slower than most

Located in:

India
  • CoA

  • GMP

  • CEP

  • FDA

  • DMF

  • + 0

All certificates

  • WC

  • CoA

Contact supplier

Replies slower than most

Located in:

Hungary

Producer

  • CoA

  • GMP

  • CEP

  • FDA

  • DMF

  • + 0

All certificates

  • GMP

  • CoA

Contact supplier

Replies slower than most

Located in:

India
  • CoA

  • GMP

  • CEP

  • FDA

  • DMF

  • + 0

All certificates

  • DMF

  • CoA

Contact supplier

Replies slower than most

Produced in:

India

Established in: 1994

MOQ: -

Employees: 4,000

All our 5 plants are top notch and FDA approved

We are a backwards integrated company

We have received 24 CEP’s and 27 USDMF’s

  • CoA

  • GMP

  • CEP

  • FDA

  • DMF

  • + 0

All certificates

  • DMF

  • WC

  • GMP

  • CoA

  • MSDS

Contact supplier

Replies quickly

Located in:

India

Producer

  • CoA

  • GMP

  • CEP

  • FDA

  • DMF

  • + 0

All certificates

  • DMF

  • WC

  • CoA

  • GMP

Contact supplier

Replies slower than most

Located in:

India

Producer

  • CoA

  • GMP

  • CEP

  • FDA

  • DMF

  • + 0

All certificates

  • DMF

  • CoA

Contact supplier

Replies slower than most

Located in:

United Kingdom
  • CoA

  • GMP

  • CEP

  • FDA

  • DMF

  • + 0

All certificates

  • DMF

  • CoA

Contact supplier

Replies slower than most

Located in:

India

Producer

  • CoA

  • GMP

  • CEP

  • FDA

  • DMF

  • + 0

All certificates

  • DMF

  • CoA

Contact supplier

Replies slower than most

Located in:

India

Producer

  • CoA

  • GMP

  • CEP

  • FDA

  • DMF

  • + 0

All certificates

  • DMF

  • CoA

Located in:

India
  • CoA

  • GMP

  • CEP

  • FDA

  • DMF

  • + 0

All certificates

  • GMP

  • WC

  • CoA

  • DMF

Located in:

India

Producer

  • CoA

  • GMP

  • CEP

  • FDA

  • DMF

  • + 0

All certificates

  • GMP

  • WC

  • CoA

  • DMF

Located in:

India
  • CoA

  • GMP

  • CEP

  • FDA

  • DMF

  • + 0

All certificates

  • DMF

  • coa

  • FDA

  • EDQM certificate

  • WHO-GMP

  • GMP

  • WC

Located in:

India
  • CoA

  • GMP

  • CEP

  • FDA

  • DMF

  • + 0

All certificates

  • DMF

  • CoA

Located in:

India

Producer

  • CoA

  • GMP

  • CEP

  • FDA

  • DMF

  • + 0

All certificates

  • DMF

  • CoA

Located in:

India
  • CoA

  • GMP

  • CEP

  • FDA

  • DMF

  • + 0

All certificates

  • DMF

  • GMP

  • WC

  • CoA

Located in:

India
  • CoA

  • GMP

  • CEP

  • FDA

  • DMF

  • + 0

All certificates

  • GMP

  • WC

  • CoA

  • DMF

How does it work?

1
Register for free
icon

You can register for free as long as you are registering on behalf of a legal company related to the pharmaceutical industry

2
Start sourcing
icon

Search in the search bar the product that you’re looking for. We’ll show you an overview of all available suppliers. Use the filters to select the relevant suppliers only

3
Send inquiries
icon

Have you found interesting suppliers? Then it’s time to contact them. Use the send inquiry button and send them a message. You can send for each product, 3 inquiries per week

4
Get quotation
icon

Suppliers get notified by Pharmaoffer that they’ve received a new inquiry. They will come back to you with their questions, certificates, and offer in the chat on Pharmaoffer. We will send you an email in case of any news

5
Arrange agreement
icon

Does the supplier meet your quality and commercial requirements? Then you can place the order. Just follow the steps of our order module

Looking for Dimethyl fumarate API 624-49-7?

Description:
Here you will find a list of producers, manufacturers and traders of Dimethyl fumarate. You can sort by certificates such as GMP, FDA, CEP, Written Confirmation and more. Send inquiries for free and get in direct contact with the supplier of your choice.
API | Excipient name:
Dimethyl fumarate 
Synonyms:
dimethyl (E) butenedioate , Fumaric acid , dimethyl ester , Tecfidera , trans-1 , 2-Ethylenedicarboxylic acid dimethyl ester , trans-Butenedioic acid dimethyl ester  
Cas Number:
624-49-7 
DrugBank number:
DB08908 
Unique Ingredient Identifier:
FO2303MNI2

About Dimethyl fumarate

So, what does it do? Dimethyl fumarate is an anti-inflammatory. It is indicated for multiple sclerosis patients with relapsing forms and is also being investigated for the treatment of psoriasis. The mechanism of action of dimethyl fumarate in multiple sclerosis is not well understood. It is thought to involve dimethyl fumarate degradation to its active metabolite monomethyl fumarate (MMF) then MMF up-regulates the Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) pathway that is activated in response to oxidative stress. Dimethyl fumarate is marketed under the brand name Tecfidera.

Check who is selling Dimethyl fumarate in the overview above.

Dimethyl fumarate is a type of Immunosuppressants


Immunosuppressants are a vital subcategory of pharmaceutical active pharmaceutical ingredients (APIs) that play a crucial role in medical treatments. These substances are designed to suppress or weaken the immune system's response, making them invaluable in various therapeutic applications.

Immunosuppressants find extensive use in the management of autoimmune diseases, organ transplantation, and the prevention of rejection reactions. By modulating the immune system's activity, these APIs help control excessive immune responses that can lead to tissue damage and chronic inflammation.

There are different classes of immunosuppressants, including corticosteroids, calcineurin inhibitors, antimetabolites, and biologics. Each class targets specific immune pathways to achieve the desired therapeutic effect. Corticosteroids, for instance, are known for their potent anti-inflammatory properties, making them effective in managing conditions such as rheumatoid arthritis and asthma.

Calcineurin inhibitors like cyclosporine and tacrolimus act by inhibiting the activity of calcineurin, a protein involved in immune cell activation. These drugs are commonly used in organ transplantation to prevent the immune system from attacking the transplanted organ.

Antimetabolites interfere with DNA synthesis and cell proliferation, thereby dampening immune responses. They are often prescribed for conditions like psoriasis and rheumatoid arthritis.

Biologic immunosuppressants, such as monoclonal antibodies, target specific immune cells or molecules involved in the disease process. They have revolutionized the treatment of autoimmune diseases like rheumatoid arthritis, Crohn's disease, and psoriasis.

Immunosuppressants require careful administration and monitoring due to their potential side effects and interactions with other medications. Close collaboration between healthcare professionals, pharmacists, and patients is essential to ensure the safe and effective use of these APIs in various therapeutic settings.

Overall, immunosuppressants represent a critical category of pharmaceutical APIs that significantly contribute to improving patients' quality of life by controlling the immune system's activity and managing various autoimmune conditions and transplantation outcomes.


Dimethyl fumarate (Immunosuppressants), classified under Immunomodulators


Immunomodulators, a category of pharmaceutical active pharmaceutical ingredients (APIs), are substances that help regulate and modify the immune response of an individual. These compounds play a crucial role in treating various immune-related disorders and diseases. Immunomodulators work by either enhancing or suppressing the immune system, depending on the specific condition being treated.

Immunomodulators are used in the treatment of autoimmune disorders, such as rheumatoid arthritis, multiple sclerosis, and psoriasis. By suppressing the immune system, these APIs help reduce the overactive immune response associated with these conditions, thereby alleviating symptoms and preventing further damage to the body's tissues.

On the other hand, immunomodulators are also employed to boost the immune system in cases of immunodeficiency disorders. These APIs stimulate the immune response, enabling the body to better fight off infections and diseases. Additionally, immunomodulators are utilized in the prevention and treatment of organ transplant rejection, where they help modulate the immune system to accept the transplanted organ.

The development and production of immunomodulators require rigorous testing and quality control to ensure their safety and efficacy. Pharmaceutical companies carefully formulate these APIs into various dosage forms, including tablets, capsules, injections, and topical preparations, to cater to different patient needs.

In summary, immunomodulators form a vital category of pharmaceutical APIs that regulate and modify the immune system. With their ability to modulate immune responses, these compounds contribute significantly to the management and treatment of various immune-related disorders and diseases, improving the quality of life for many patients.



Dimethyl fumarate manufacturers | traders | suppliers

We have 30 companies offering Dimethyl fumarate produced in 9 different countries.

Get in contact with the supplier of your choice:

  • Shilpa Medicare Ltd from India, product country of origin India
  • Tofigh Daru from Iran, product country of origin Iran
  • Dr. Reddy's from India, product country of origin India
  • PluviaEndo from Turkey, product country of origin Turkey
  • Laboratorium Ofichem B.V. from Netherlands, product country of origin Netherlands
  • Senova Technology Co., Ltd. from China, product country of origin China
  • LGM Pharma from United States, product country of origin World
  • Unichem Labs. from India, product country of origin India
  • Yabao Pharma from China, product country of origin China
  • PLIVA from Czech Republic, product country of origin Croatia
  • Arevipharma from Germany, product country of origin Unknown
  • Natco Pharma from India, product country of origin India
  • Teva API from Israel, product country of origin Unknown
  • Chongqing Huapont from China, product country of origin China
  • Sionc Pharma from India, product country of origin India
  • Chinoin from Hungary, product country of origin Hungary
  • Torrent Pharma from India, product country of origin India
  • Vasudha Pharma Chem Ltd. from India, product country of origin India
  • Honour Lab from India, product country of origin India
  • Alkem Labs. from India, product country of origin India
  • Intas Pharma from United Kingdom, product country of origin Unknown
  • Raks Pharma from India, product country of origin India
  • Micro Labs from India, product country of origin India
  • Glenmark Pharma from India, product country of origin India
  • Mylan from India, product country of origin India
  • Optimus Drugs Pvt Ltd from India, product country of origin India
  • Biophore India from India, product country of origin India
  • Sun Pharma from India, product country of origin India
  • Granules India from India, product country of origin India
  • MSN Organics from India, product country of origin India

Let the supplier know whether you are looking for a product with a specific monograph such as EP (Ph. Eur.), USP, JP, BP or another quality. Or, whether you are looking for hydrochloride (HCl), anhydricum, base, micronisatum or a specific purity.

You can use the filters to find high-quality suppliers. For example, you can select GMP, FDA or ISO certified suppliers. Visit our FAQ page or use the chat box in the corner to get more information about Pharmaoffer.